Based at the JGU Mainz, the Challenges profile area is supported by various partners in Rhineland-Palatinate and the Rhein-Main region; it also maintains a number of multi- and bilateral collaborations with diverse regional, national and international institutions. There is a particularly close interaction with the Leibniz Research Institute for Archaeology and its locations in Mainz and castle Monrepos/Neuwied, as well as the Roman-Germanic Central Museum (Römisch-Germanisches Zentralmuseum [RGZM]) and the Leibniz Institute for Resilience Research (LIR) in Mainz. Further key components are the Archaeological Association Rhine-Main (Verbund Archäologie Rhein-Main [(VARM]), founded in 2016, and the Center for Ancient Languages and Scripts (Zentrum für Alte Sprachen und Schriften [ZASS]), launched in 2020, under whose framework intensive cooperation takes place between JGU, GU Frankfurt, TU Darmstadt, Mainz University of Applied Sciences, the Romano-Germanic Commission (Römisch-Germanische Kommission [RGK]) of the German Archaeological Institute in Frankfurt, and the state heritage offices and museums of the region. In addition, the profile area is in constant contact with numerous researchers around the world through its diverse research projects.